Sentence examples for apl model from inspiring English sources
In this study, we use an altered peptide ligand (APL) model and multi-dimensional flow cytometry to evaluate polyfunctionality of TCR gene-modified T cells.
Our in vivo study was carried out on a well-established transgenic APL model which develops leukaemia 14 days after transplantation (de Figueiredo-Pontes et al., 2011).
To understand whether HIF-1α inhibition led to LICs elimination especially upon ATRA treatment, we turned to a mouse APL model (Minucci et al, 2002).
Synthetic phosphoethanolamine has anti-leukaemic effects in an APL model by inhibiting malignant clone expansion, suggesting that it is an interesting compound for leukaemia treatment.
In vivo Pho-s exhibits anti-proliferative effects in APL model reducing the number of CD117+ and Gr-1+ immature myeloid cells in the BM, spleen and liver.
We therefore analyzed RA-induced differentiation of NB4 cells, a well-established APL model of granulocytic differentiation, in which Ago2 mRNA and protein were silenced.
In fact, VPA treatment in an APL mouse model failed to target leukaemia-initiating cells and only resulted in transient responses (Leiva et al, 2012).
Although suppression of HDAC1 prolonged disease latency in APL mouse models, inhibition of HDAC1 (and HDAC2) would accelerate APL pathogenesis in the early transformation stage owing to its effect on the expansion of a subset of APL cells with leukaemia-initiating features (Santoro et al, 2013).
As a consequence, inhibiting HIF-1α in APL mouse models delays leukemia progression and exquisitely synergizes with ATRA to eliminate leukemia-initiating cells (LICs).
In acute promyelocytic leukaemia (APL) animal models and in APL cell lines, synergism among three active compounds isolated from the three components of a TCM formula was also demonstrated [ 90].
An APL-developed modeling and simulation component of the project, called STRATAM (for Surface Transportation Technology Assessment Model), simulates the process of people moving through a transit system and helps translate raw measurements into performance requirements for sensors.
