Sentence examples for apl it from inspiring English sources

Based on studies using altered peptide ligand (APL), it is well established that T cell recognition of peptide epitopes is focused upon a few TCR contact residues [ 9].

Arsenic trioxide (As2O3; ATO) is clinically effective in treating acute promyelocytic leukemia (APL); however, it frequently causes cardiotoxic effects.

The Apl subclade it predicts was also supported by the protein tree of Christensen et al. [ 17].

ATO used to be a second-line treatment for relapsed or refractory APL; however, it has gradually become the first-line choice in newly diagnosed APL 39, 40.

In elderly APL patients, it would be of particular interest in how far the amount of chemotherapy could be reduced when prolonged ATRA was administered.

To identify a peptide that did not cause anaphylaxis in vivo we chose to pursue the 37Ala APL because it involved alteration of a residue outwith the published core T cell epitope of 40 48 [ 11].

ATRA is successfully used in the treatment of acute promyelocytic leukemia (APL), where it induces granulocytic differentiation of the blast and subsequent cell death of the differentiated leukemic cells.

Although the aberrant recruitment of transcriptional co-repressor complexes by RARalpha is critical for APL pathogenesis, it becomes evident that the recruitment of opposing activator complexes upon ATRA treatment has a central role in mediating treatment response (Mikesch et al, 2010).

Third, we find that sleep loss due to VGAT-RNAi expression in APLs, when it is seen, is accompanied by increases in nighttime activity while awake, which is never seen with DPM-driven VGAT-RNAi expression.

The multiple mechanisms of action of ATO suggest that it may have antitumour activity in malignancies other than APL and that it may be used in combination with other agents.

ATRA treatment up-regulates LRRC25 expression in APL blasts, whether it could be a response marker for ATRA-based differentiation therapy needs to be further studied.