Sentence examples for apc n from inspiring English sources

However, there was no statistically significant difference between patients receiving placebo (n = 38) or APC (n = 37) in the number of ventilator-free days (median [25-75 [25-75quartile range]: 19 [0-24] vs. 19 [14-22], respectively; P = 0.78) or in 60-day mortality (5/38 vs. 5/37 patients, respectively; P = 1.0).

A total of 44 male Lewis rats were randomly assigned to receive intravenous injections of 15 mg/kg lipopolysaccharide alone (LPS) (n = 11) or LPS followed by subsequent injection of 2 mg/kg recombinant human APC (LPS + APC) (n = 11), whereas control animals received either APC (n = 11) or saline (n = 11).

The intervention consisted of APC (N = 16) administered intravenously for 96 hours with a dose of 24 μg/kg/hour or placebo (N = 16) with a similar infusion rate.

Here we show that, in three distinct experimental model systems, expression of an N-terminal fragment of APC (N-APC) results in loss of directionality, but not speed, of cell motility independently of changes in β-catenin regulation.

The APC N-terminal is a region that contains seven armadillo repeats [2] through which it binds KAP3 (kinesin-associated protein 3), Asef (Cdc42/Rac-specific guanine nucleotide exchange factor) and IQGAP1 (IQ motif containing GTPase activating protein 1) [3]–[5].

All 464 samples without a truncating APC mutation (n = 411) and all samples with absent hMLH1 expression (n = 58) were analysed for mutations in the phosphorylation sites at codons 33, 37, 41 and 45 in exon 3 of the CTNNB1 gene.

No-aPC patients (n = 9) did not show any change in the microcirculation over time.

Immunostaining for APC and N-cadherin in control human fetal testis xenografts demonstrated Sertoli cell cytoplasm distribution around the germ cells, similar to that in rats.

APC, espin, N-cadherin, and vimentin have established roles in Sertoli germ cell interactions (Bartles et al. 1996; Chen et al. 1999; Kleymenova et al. 2005; Strelkov et al. 2003; Tanwar et al. 2011; Vogl et al. 2008).

APC combines an N-terminal Armadillo repeat domain (Arm rpts) with a more C-terminal intrinsically disordered region; each contains binding sites for multiple partners.

Such a model might also be able to better integrate previous studies showing that APC shields the N-terminus of β-cat from dephosphorylation (Su et al., 2008).