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And when the symptoms begin to take your life apart, it is difficult to recover.
"Now that multilateral trade talks under the World Trade Organization have fallen apart, it is difficult for Japan to compete in the global marketplace without bilateral free trade agreements," Hiroshi Okuda, chairman of Nippon Keidanren, Japan's most important business group, told reporters last week.
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Indeed, there seems to be a touch of genius about Capello's entire management strategy given England are now consistently delivering performances of such assurity - a bad 35 minutes in Kazakhstan apart - it is difficult to believe they failed to score in the first-half of their last meeting with Andorra in September.
Now, apart from Gierak groups, it is difficult for other groups to use the Ga+ source focused ion beam system to fabricate nanopore with diameter less than 10 nm.
Apart from direct observation, it is difficult to obtain a fully accurate measure of medications that the patient is taking but previous studies have shown that medication claims are a good approximation of medication consumed [ 19, 24].
But apart from the initial savings, it is difficult to gauge whether Vodafone and its competitors are going to profit.
In the event, the convoy pushed through using military force and the Taliban suffered substantial losses, but, apart from the propaganda victory, it is difficult to see what has been achieved.
At any given moment, apart from peak growing season, it is difficult to bring the full reality of the garden into focus.
Apart from obviously false citations it is difficult to find a universally accepted definition or even a numerical cut-off value for the unscientific use of self-cites.
Apart from the H275Y marker, it is difficult to predict the effect of natural genetic variation in HPAI (H5N1) viruses on susceptibility to NA inhibitors in humans.
However, when the size of a specimen is small, other effects may also impact its mechanical properties and it is difficult to tell them apart.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com