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When the M10713 was subsequently identified as an indicator strain against NHBA and subsets of sera were tested by hSBA, all subjects receiving two doses either 1 or 2 months apart achieved an hSBA titer ≥4 after the second vaccination.
This observation concurs with data generated with AS03A adjuvanted A/Vietnam/1194/2004 (H5N1) vaccine which showed that two doses given 6 months apart achieved equivalent seroprotection after the second vaccination when compared to two doses given 21 days apart [ 17].
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Apart from achieving the projected numbers, achieving them with minimal adverse events (AEs) is essential.
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We have found that the precise additive and multiplicative tuning necessary to maintain the delicate balance of excitatory feedback can be performed by a dual control system within the framework we study here if the target firing rates are set far enough apart to achieve a large characteristic firing rate variance.
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