Your English writing platform
Free sign upSuggestions(1)
Exact(5)
This reduced repressive activity allows Hand2 to be upregulated, causing the general AP shift.
We therefore see no clear evidence against our hypothesis that an AP shift was involved in the fin-to-limb transition.
However, in the experiments extensive Shh signalling triggered by RA causes a similar AP shift, but through a different mechanism inhibiting production of Gli3 repressor form (rather than altered regulation of Gli3 transcription).
Although the detailed validity of this model is unclear (Wagner and Larsson, 2007), there is a possibility that an AP shift in molecular patterning was involved in the acquisition of digits.
In other words, the AP shift during evolution was partially driven by cis-regulatory changes, while by contrast in our RA experiments it was driven by a Shh-mediated effect on the Gli3 protein itself, but in both cases achieving similar phenotypic changes.
Similar(55)
Using other markers, AP shifts have also not been seen in ventralized embryos after dpp and tld KD (see anterior sim stripe in Figure 2F,R).
Although expression of Hoxa13 in RA treated embryos was slightly weaker than in control embryos, nevertheless PD patterning appears hardly affected compared to the clear AP shifts in Hand2 and Pax9 expression (as the PD boundary of Hoxa13 expression is the same as controls, Figure 4E).
This is likely because sufficient soil nutrients, especially AP, could shift species composition in favor of less efficient mutualists by plants allocating less biomass and energy to roots (Johnson 1993).
(AP) GIANTS' BULLUCK MAY SHIFT The Giants are experimenting with the free-agent acquisition Keith Bulluck as an outside linebacker, leaving the middle to the third-year player Jonathan Goff.
Military analysts here, com menting on this apparent change, say that the shift ap pears to have resulted more from the accidental bombing of a factory near Cairo sev eral weeks ago and the kill ing of schoolchildren more re cently than from the installa tion of Soviet ‐ made SAM ‐ 3 missiles.
Increasing electrical coupling produces a transition from this pattern to the symmetrical AP pattern (phase shift Φ = 0.5) (see horizontal dashed line area, Fig. 2C1).
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.
Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com