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Current protocols for assembling variant gene libraries have evolved from the relatively simple early protocols that generated random variability through error prone PCR [1] into a rich variety of protocols that allows introduction of virtually any type of variation in any given gene [2], [3], [4].
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eMLPA, here applied on an inducible Pkd1 conditional deletion mouse model, simultaneously measures both the reduction of the floxed allele and the increase of the deletion allele in a single reaction thereby minimizing any type of experimental variation.
The results obtained show that the decrease of tensile strength with increasing diameter of the rod is related to the nonuniformity of stress distribution near the grips, independent of any type of size dependent variation in material strength.
The combination of restricted variation in potentially deleterious directions and feedback between variation and stress, explains how any type of newly-forming random variation can self-organize into emergent physiological adaptations.
The total amount of mitochondria in skeletal muscle is strictly proportional to maximal oxygen consumption, in all types of variation.
Specificity for distinguishing any type of outbreak from random variations in illness trends may be low if statistical detection thresholds are reduced to enhance sensitivity and timeliness.
It is this type of variation that Beethoven began to pursue in his final period.
Variations over a bass were the most popular and important type of variation in the Baroque era, but composers continued to write other kinds as well.
Another type of variation relates to eye size as measured in dimensions or number of ommatidia.
At equatorial stations (TIR and KOD), a very large and "inverted V" type of variation is observed with noon maximum in H field and is the characteristic of an equatorial electrojet type of variations.
Here, also, at equatorial stations (TIR and KOD), a very large and "inverted V" type of variation is observed with broad noon maximum in H-field, and is the characteristic of an equatorial electrojet type of variations.
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