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In combination with a series of amplicons that range in size from 100 400 bp (i.e. reflective of amplicons used in real-time qPCR), LRE analysis demonstrated that neither GC content nor amplicon size had any substantive impact on fluorescence intensity (Figure 5).
None of these had any substantive impact on the results (data not shown).
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The conclusion was that the forums had "a substantive impact on election outcomes" only a few times.
Housing assistance, he said, "is an investment that has an immediate return and a substantive impact on people that are living below the poverty line".
Did the Tories back the government's VAT cut, which had a "substantive impact" on the economy (according to the IFS) and helped provide an "immediate boost" to consumer spending (according to the CEBR)?
Gallup reports that their "election polling trends since the advent of televised presidential debates...reveal few instances in which the debates may have had a substantive impact on election outcomes".
Thus, any potential errors in the assignment of specific physicians to specific practices appear to be too infrequent to have a substantive impact on model results.
Price has a substantive impact on choice alone, while a strong brand name is helpful for the service provider only in the consideration stage.
Several authors have suggested the founding period as a critical time in the development of a firm, arguing that the resource and decision choices made at this point have a substantive impact on the firm's future.
We conclude that a vaccine of moderate efficacy and duration could have a substantive impact on gonococcal prevalence, and disease sequelae, if coverage is high and protection lasts over the highest risk period (i.e., most sexual partner change) among young people.
While his executive orders have garnered a lot of hype, a majority of them have not yet had a substantive impact on actual policy.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com