Aoyama, who has since left the government agency to work at Fukushima University, has accumulated substantial knowledge on the movement of Fukushima-derived radionuclides in the ocean, which is valuable to operators of coastal nuclear power plants.
Although other cases are not considered, it is useful to state that there also exists substantial knowledge on the parameters of this cellular pattern for other types of population, i.e. children [29], animals [30] and also for abnormal endothelia [31].
South Africa's antiretroviral treatment programme, the largest worldwide with recent notable increases in coverage, has generated substantial knowledge on how to improve adherence, tracing defaulters, and enabling patient participation through treatment literacy and patient support groups (5).
Kuczynski's study on the Cameroons and Togoland, published in 1939, was the first critical investigation of information on the population of Africa and was largely negative concerning the possibility of substantial knowledge on the basis of the information then available (99).
While we have acquired substantial knowledge on how EVs can directly exert a detrimental impact on beta cell function and viability, we still lack a mechanistic explanation for how this infection could also trigger or aggravate the loss of self-tolerance toward beta cells.
The basic idea of 'visual proteomics' to map molecular landscapes inside unperturbed cellular environments into a quantitative description of macromolecular interactions that underlie cellular functions (Nickell et al. 2006) did obviously not generate (yet) new substantial knowledge on the secretory pathway including Golgi apparatus.
"However, it may also be that light-drinking mothers tend to be more relaxed themselves and this contributes to better behavioural and cognitive outcomes in their children". The study aimed to fill the substantial knowledge gap on the impact of women's drinking on their babies, which has led to conflicting and confusing advice from health bodies and government.
While resource efficiency is already on the political agenda (EU and national resource strategies), there are still substantial knowledge gaps on the effectiveness of resource efficiency improvement strategies in different fields.
In recent years, substantial knowledge accumulated on the genetic consequences of the climatic oscillations in the Quaternary for European and North American species [e.g. [ 1- 4]].
A substantial knowledge base exists on the use of this 40-year-old technology.
