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Discover LudwigThe phrase "any substantial differences between the two" is correct and usable in written English.
You can use it when discussing or comparing two items, concepts, or entities to inquire about significant distinctions.
Example: "In our analysis, we need to determine if there are any substantial differences between the two proposed solutions."
Alternatives: "any significant differences between the two" or "any major differences between the two."
Exact(1)
In general, there were not any substantial differences between the two groups.
Similar(59)
There's a substantial difference between the two".
The results indicate a substantial difference between the two latent classes.
Importantly, the overall impact of sugar availability on malaria vectorial capacity reflects a substantial difference between the two sites.
There were no substantial differences between the two randomised arms on any baseline variables (Table 1).
There are substantial differences between the two cases.
But there are very substantial differences between the two groups.
The Senate bill, once completed, must be reconciled with the bill adopted by the House last month, and there are substantial differences between the two.
However, even 100 years ago there were substantial differences between the two cities.
The results showed no substantial differences between the two tested methods on hydrolysis yield.
The comparisons of migrant group characteristics undertaken in this section reveal some substantial differences between the two migrant groups.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com