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The immunodominance of T cell responses, or the relative proportion of the overall response attributable to any one given epitope, is governed by many factors[1].
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Despite the immense recombinatorial potential within the TCR repertoire, identical or closely related receptors specific for any given epitope are observed frequently in multiple individuals sharing a major histocompatibility complex (MHC) restriction molecule [ 24, 28].
To account for the lack of therapeutic activity of mAbs, we can speculate that HMGB1 in vitro avidly may bind different molecules, thereby preventing HMGB1-specific mAbs from recognizing any given epitope of the HMGB1 molecule.
For each epitope, the intensities of the epitope precursor(s) and the optimal epitope were combined for the calculation of the total epitope production of a given epitope ("epitope yield").
If a given epitope-precursor fragment contained a promiscuously presented epitope and/or more than one epitope, we summed the frequencies of all HLA variants that could present the epitope(s) encoded by that epitope precursor.
When it's ordinary, no one gives me any attention.
"No one gave us any hope but I think we have won a lot of admirers.
No one gives me any answers.
At the time, no one gave a thought to any of these horses as racers.
No one gave the young Bajaj any chance of a comeback.
No one gives Paul Rhoads and the Cyclones any respect.
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