In any given cell, all but one gene of these families are repressed by compact chromatin structures.
The reasons for this approach to tumor classification are: 1. Organs may have multiple embryologic derivatives (e.g. skin contains tissues of ectodermal, neuroectodermal and mesodermal lineages), but any given cell has only one lineage.
And there is a huge dynamic range in any given cell at any given time.
The more difficult step in the reconstruction procedure is the first one: given a cell value, a stationary solution of the system has to be found whose average at the cell equals the given value.
Neighboring cells may reuse the same slot; each slot can only be assigned to one MS within a given cell, that is, there is no intracell interference.
This would imply that in a given cell, one HAT is recruited to a particular locus, while in another cell, a distinct HAT is recruited instead to the same locus.
Moreover, where multiple TSSs exist for a gene, as in many imprinted loci, H3K36me3-mediated DNA methylation may serve to ensure the dominance of one promoter in a given cell type.
Because many vaccine viruses undergo limited replication relative to wild-type viruses (e.g., Hambleton and Gershon 2005; Monath 2005; Monath et al. 2008; Whitehead et al. 2007; Condack et al. 2007; Miki and Chantler 1992), it would initially seem unlikely that more than one virion would enter a given cell.
The majority of mathematical models assumes that only one virus can infect a given cell at a time.
For example, one can ask, for a given cell, which gene-products are responsible for energy metabolism, and which are involved in cell cycle and cell fate decisions.
