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One difficulty with any such analysis in mammals, however, is that, nucleotide usage in ESEs trends to go in the same direction as predictions from the cryptic splice avoidance model (Chamary and Hurst 2005).
This is one difficulty to further study the problem on step-like contrast structures.
One difficulty with adiabatic quantum computation is the limit on the computation time.
One difficulty is that East and West are slippery categories.
One difficulty is that Prospero never comes fully alive.
One difficulty is that Francis made an unwieldy 290 recommendations.
One difficulty has been figuring out what to measure.
One difficulty is that these villages are so remote.
Monthly cross-country airplane trips solved one difficulty, but the other took more work.
One difficulty will be in deciding how to tell whether a vaccine works.
However, one difficulty I struggle with is, for lack of a better term, "compassion fatigue".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com