Sentence examples for any of leptin from inspiring English sources

However, it is difficult to elucidate the role, if any, of leptin during inflammatory conditions in human patients as different clinical studies have so far yielded inconsistent results, suggesting that leptin has a rather complex role in immune response and inflammation in humans.

Although TIMP-1 is highly expressed in cartilage and reduced in OA, we failed to detect any effect of leptin on its expression (data not shown).

The use of cartilage explants instead of isolated chondrocytes may explain the discrepancies because other authors were unable to find any effect of leptin on the expression of iNOS in cultured human primary chondrocytes [ 9, 14].

For example, we have recently found that when leptin-naïve children with congenital leptin deficiency are treated with leptin there is no change in circulating CRP concentrations (Farooqi and O'Rahilly, 2007), and we have been unable to find any antagonism of leptin actions in mice co-treated with leptin and a 6-fold molar excess of highly purified CRP (Hutchinson et al., 2007).

However, other authors failed to observe any direct effect of leptin on the synthesis and degradation rates of proteins in skeletal muscle of rats [36], suggesting that leptin effects on muscle mass may be mediated by the release of a secondary growth factor.

We failed to observe any protective effect of leptin when it was administered at onset of MCAo.

Nonetheless, we did not observe any significant effects of leptin replacement on fasting insulin secretion or total insulin output during an OGTT (Fig. 1).

There was no colocalization of Lepr and PrRP in either brainstem region, suggesting that any direct central effects of leptin are likely to be via the DMH population.

Jon: Imagine you have 200 pounds of excess weight on your body, but your brain is not getting any of the leptin signals.

We did not observe any increase in ObRb expression as a result of leptin, amylin, and/or leptin+amylin administration for 30 min compared with the control.

"The idea is that in the absence of leptin you're fat, so leptin keeps you thin," he explained.