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A founder effect amplifies any mutation present in a small population that later expands.
This kind of change in state of gene expression is called epigenetic: it is self-perpetuating and it occurs without any mutation of the DNA.
What we don't yet know is whether any mutation it undergoes will make it more or less severe.
Any mutation that results in a lack of function for a particular gene is called a "null" mutation.
In addition, ePiggyBac transgenes can be removed from the hESC genome without leaving any mutation.
The PCR products were gel purified and sequenced to identify any mutation.
Several aromatic accessions did not carry any mutation in the coding segments we sequenced.
The individuals were mated with P c = 1 and their offspring were not subjected to any mutation.
However, we did not observe any mutation at these sites by sequencing (Additional file 5: Table S1).
Antibiotic resistance in these beneficial microbes, either intrinsic or due to any mutation does not manifest a safety concern in itself.
It has not escaped our notice that the design of these molecules makes possible the production of similar controls for virtually any mutation or sequence of interest.
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