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The phrase "any major problems" is correct and usable in written English.
It can be used when inquiring about significant issues or difficulties that may have arisen in a situation or project.
Example: "Before we proceed with the next phase, I want to check if there are any major problems that we need to address."
Alternatives: "any significant issues" or "any critical concerns".
Exact(60)
"That is two uninterrupted by any major problems.
When you first came to the Emelin, were there any major problems?
It has been a great tournament so far without any major problems.
Both Holland and Spain issue foil through needle exchanges without any major problems.
That's the most complicated part; I haven't had any major problems arise with anything else.
The sale is contingent on the plants' running at full capacity, without any major problems.
Groomes said police haven't seen any major problems with the crew in the past two months.
She said she did not know of any major problems in her sister's family.
The operations of the device are reliable and have not produced any major problems.
Mr. Nussbaum added that he did not think there would be any major problems with rescheduling tests.
"I don't think anyone has any major problems not being able to have a drink," said the Birmingham City forward.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com