The phrase "any major modifications in" is correct and usable in written English.
It can be used when discussing changes or alterations that are significant in nature, typically in a formal or technical context.
Example: "Before we proceed with the project, we need to assess if there are any major modifications in the original plan."
Alternatives: "any significant changes in" or "any substantial alterations in".
Of these, the spectral conversion is the most promising cost-effective approach, which does not involve any major modifications in the solar cell architecture or usage of complicated costly optics.
Even though we could not detect any major modifications in myelin structure in Ins2Akita/+ PNS (Fig. 3A C), subtle molecular alteration in myelin gene expression could provide an early marker of later stage irreversible pathological changes.
Moreover, Ghezzi et al. [ 14] over a follow-up of 3 years, did not register any major modifications in volume reduction or symptom improvement.
The approach adopted for this study is innovative in the sense that both conventional and phase contrast imaging can be performed within same experiment hutch without any major modification in the experimental hutch or collimator.
It is true that we did not observe any major modification in terms of number/proportions or suppressive functions in the various lymphoid organs (spleen, mesenteric and pancreatic lymph nodes) recovered from protected wild-type NOD mice.
Analyses of these questionnaires showed very small differences between the sites in the implementation process and did not identify any major modification in the implementation of the interventions in any site.
Higher eukaryotic cells utilize tyrosine phosphorylation as a major modification in signal transduction pathways in response to extracellular stimuli.
This time window was reduced to one minute for the software version 1.07 and higher as a major modification in order to improve cardiac output measurement.
33 We suppose that blMCI subjects who present a major modification in walking variables during WTMT are more at risk to evolve towards an MCI state, even to dementia.
They operate at fixed bit rates and bit rates cannot be altered without major modifications in the vocoder design.
