The phrase "any major modification" is correct and usable in written English.
It can be used when discussing changes or alterations that are significant in nature, often in contexts like contracts, agreements, or project plans.
Example: "The project will proceed only if there are no major modifications to the original design."
Alternatives: "any significant change" or "any substantial alteration".
The sampler has been used for more than 15 years without any major modification.
The predictions of this SDR based LES closure in the ORACLES burner and Volvo Rig configurations exhibit good agreement with experimental results without requiring any major modification to the model parameters.
The approach adopted for this study is innovative in the sense that both conventional and phase contrast imaging can be performed within same experiment hutch without any major modification in the experimental hutch or collimator.
Additionally, 2-Phase algorithm [14], which enumerates tree-like hydrogen-suppressed chemical graphs, can be used without any major modification to enumerate such trees T=G−e with one edge deficit from 1-augmented trees G to be constructed.
Phenotypic analysis of various lymphoid organs (spleen, mesenteric, pancreatic lymph nodes) did not reveal any major modification of the T cell compartment as compared to untreated NOD mice (data not shown).
It is true that we did not observe any major modification in terms of number/proportions or suppressive functions in the various lymphoid organs (spleen, mesenteric and pancreatic lymph nodes) recovered from protected wild-type NOD mice.
"We don't anticipate any major modifications to the airplane," Mr. McNerney said.
It did not say what the conditions were, but official sources told AFP that Chinese investors were given permission to resume work on the project without any major modifications.
But if the dissenters fail to obtain any major modifications to the deal, they would look foolish, particularly as they go about spending millions of dollars more from state treasuries that no longer enjoy surpluses.
The possibility of achieving self-humidified operation of a polymer electrolyte membrane fuel cell, without any major modifications to the conventional fuel cell design, is investigated experimentally.
Of these, the spectral conversion is the most promising cost-effective approach, which does not involve any major modifications in the solar cell architecture or usage of complicated costly optics.
