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The strain did not produce any lactate, and only very low amounts of acetate, ethanol, and butyrate.
Univariate analysis in our study shows that any lactate ≥2.0 mmol/l had 1.10 times increased possibility of admission per unit increase in lactate (95% CI 1.07 to 1.13, p < 0.001).
In contrast, unchanged blood lactate levels would be expected under low-intensity exercise conditions and are indicative of oxidative metabolism and the ability of the body to use any lactate that is produced [16].
Once glucose is administered, the cortex continues to produce little, if any, lactate.
In CM1 medium, hardly any lactate was produced by both strains.
If lactate were truly 'preferred' over glucose, why is any lactate released from brain during rest or activation?
Similar(51)
In fact, as for any metabolite, lactate concentration depends on the ratio between production and consumption.
However, we did not observe any change in lactate production, despite significantly lower glucose uptake (Fig. 7).
One would expect therefore that this very large reserve capacity of the liver would be able to overcome any contribution of lactate from an extra-hepatic source maintaining lactate concentrations low.
Because metformin decreases liver uptake of lactate, any condition that may precipitate lactic acidosis is a contraindication to its use.
Lactate clearance was defined as any decrease in lactate within 12 hours from baseline, or an initial lactate <2.0 mmol/l [ 12, 16].
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