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In WT mice, the duration of AD reached about 30 s by the 14th stimulation and additional stimulation did not induce any further prolongation of AD duration.
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This supra-therapeutic level was associated with a further prolongation of PT, aPTT, and the EXTEM variables CT and CFT.
This supratherapeutic level was associated with a further prolongation of PT, aPTT, and the EXTEM variables CT and CFT.
Addition of 5 μmol/L ranolazine did not pronounce this effect while 10 μmol/L caused a further prolongation.
Conversely, a higher concentration of ranolazine at 10 μmol/L led to a further prolongation of APD90 when added to d-sotalol compared with d-sotalol alone.
However, as U-1810 cexpresspress mutant p53, upon silencing of miRNA-214 level of p27Kip1 increases, leading to a further prolongation of the G2 arrest and subsequently to senescence.
16. Underlines that a further prolongation of the existing internal border controls – or the reintroduction of new ones – would impose major economic costs on the EU as a whole by severely damaging the single market.
Further prolongation of the activation process is disadvantageous as it leads to the burn-off of the sample and the increase of the micropore diameter and, finally, reduction of hydrogen sorption ability.
It becomes imperative when the preclinical development compound itself prompts an even further prolongation of a very tightly focused, additional analog program specifically directed toward the final refinement of drug metabolism-related pharmacokinetic (PK) properties or the remediation of a distinct toxicity concern.
In conclusion, oral maintenance tocolysis has no significant impact on further prolongation of pregnancy after intravenous tocolysis.
▪ carbon storage strategy: development of large forest carbon stocks through limited timber harvesting, further prolongation of rotation period, share of residues and target diameter for harvesting increased.
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