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Current technology would allow us to express an activated form of the Erbb4 receptor specifically in cardiomyocytes, yet any downstream effect could be due to activation of Nrg1- or non-Nrg1-mediated pathways.
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In addition, no evidence of any alteration in protein kinase C-α within the tumors or any downstream effects leading to apoptosis were observed.
A bias towards binding of either isoform may determine any downstream effects.
b) Critique: Are there any downstream effects of the cells exposed to low shear to those exposed to higher shear?
Are there any downstream effects of the cells exposed to low shear to those exposed to higher shear?
Clearly, integrative proteomic and genomic approaches are needed to characterize these OP protein biomarkers and validate them with any downstream effects.
The initial TNF-α and IL-6 concentrations were chosen as primary end-points because endotoxin has been shown to induce a quick and reproducible response both in vitro and in animal models [ 20], and at 1 and 2 hours it is unlikely that any downstream effects will affect the result to any great extent.
But the income disparities are a downstream effect of the human capital and geographic disparities.
"Whether they come as a downstream effect of the building blocks of basic research work someone else has done, or in a more deliberately applied way.
However, there is a dangerous lack of any sense of incongruity that human and domestic animal public health interventions occur only as a downstream effect of wildlife concerns.
The alkalisation of the apoplast is a downstream effect of signalling processing by MAPKs.
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