These mechanical stimuli are thought to produce downstream alterations in intracellular ion concentrations, which ultimately give rise to increased biosynthesis.
These results linked variant TCL1A SNP sequences that are associated with AI-dependent musculoskeletal pain with increased E2-dependent TCL1A expression and with downstream alterations in cytokine and cytokine receptor expression as well as NF-κB transcriptional activity.
In addition, due to the significant structural difference between Kbz and other histone marks, it is tantalizing to speculate the possible existence of specific proteins or domains that recognize Kbz and cause diverse downstream alterations in chromatin, providing an additional layer of control over gene transcription26.
The changes in the second messenger activity lead to downstream alterations in gene expression and resulting in an acceleration of the osteoblasts activity by upregulating bone-specific genes [31].
In most tissues, transcription-generated RNA base sequences experience downstream alterations; this ubiquitous process is particularly active in the nervous system [77].
Second, downstream alterations leading to constitutive activation of AKT and MAPK signalling pathways impede EGFR inhibitor activity.
We show that TLR2-induced migration/invasion is partly mediated by β1-integrin and downstream alterations in cytoskeletal dynamics.
The persistent increase in brain glutamine and alanine levels could either be induced by the infusion itself or by downstream alterations with reduced consumption of glutamine and alanine.
Furthermore, we show that TLR2-induced migration/invasion is partly mediated by β1 integrin and downstream alterations in cytoskeletal dynamics and Rac1 activation.
The other possibility is that progerin may directly inhibit an essential adipogenic gene via physical interaction, whose mis-regulation triggers downstream alterations in transcription.
Finally, I exploited the sets of significant targets of driver TFs to find other drivers in the same tumor type causing similar downstream alterations, under the hypothesis that somatic alterations of different drivers in the same or cross-talking pathways may converge in the downstream alteration of the expression of similar groups of genes (Additional file 1: Figure S1D).
