Our investigation proves that parallel with changes of lipophilic character and extent of plasma protein binding properties of Pa derivatives a consequent alteration occurs in their pharmacokinetic behavior without losing the pharmacodynamic effect.
Given these observations, it is possible that the reported perturbation of mitochondrial transport associated with Alzheimer's disease is caused by an elevated level of HDAC6 and a consequent alteration of the cellular trafficking machinery.
Indeed, a possible explanation of our results could lie in the dysfunction of the blood-brain barrier, in which astrocytes are localized, with a consequent alteration of the transport of prostaglandin, the final signal transduction mediators from the periphery to the brain during fever response [50], [51].
This could have led to a reduction in the cognitive load and a consequent alteration of the testing conditions.
As increased C2 production is not joined by a similar increase in C1 production, there is a consequent alteration in the C2 C1 ratio.
3, 4 Hypertensive individuals have decreased blood flow and vascular conductance at rest, which reduces their vasodilator reserve, with a consequent alteration of vasodilator responses.
The release of gases and particulate matter into the atmosphere from factories and similar sources has increased dramatically in recent years, with consequent alterations in the chemistry of rainwater.
Modulation of spinal nociception from the anterior hypothalamus/preoptic area (AH/POA), and consequent alterations in the pain experience may contribute to integrated responses brought into play during fear or stress and as part of the sickness response.
This region has been experiencing changes in its forest cover and consequent alterations in functional abilities of its ecosystem.
These results suggest that maternal ethanol ingestion can affect synaptic function in the developing central noradrenergic system, with consequent alterations in neurotransmitter uptake and storage.
Reduced nitrate uptake affects nitrogen assimilation (Silveira et al. 2001; Qu et al. 2011), with consequent alterations in amino acid and protein metabolism (Surabhi et al. 2008; Younis et al. 2009; Maaroufi-Dguimi et al. 2011).
