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An exit screen in which all women receive both tests would help to minimise any ascertainment bias.
We first describe results for the general population, in which nuclear families were generated without any ascertainment on disease.
In order to minimize any ascertainment bias, all the genotype phenotype correlation analyses were performed on relatives and probands separately.
We appreciate that cancer risk estimates, obtained from informative and a priori free of any ascertainment bias data, by Hwang et al (2003) are quite similar to ours.
Based on the results of this assessment, it may be necessary to adjust the recorded number of hospital admissions for any ascertainment bias identified.
Hence, the flat distribution witnessed in figure 2 indicates that derived alleles occur at high frequency more often than expected and that this was not due to any ascertainment bias.
Similar(50)
The echocardiographic data could not be analysed simply by combining all the measurements, as this would create an ascertainment bias (those with any observed deterioration would be more likely to have more scans and therefore contribute disproportionately to the results).
However, there is no reason to suppose that this process would be differential by post code, and any incomplete ascertainment for more recent years of birth would be similar for all study locations.
We believe that, for severely affected individuals, there would be little if any differential ascertainment by SES, but for mildly affected individuals, the bias would, if anything, reduce the size of the association.
Any unaccounted ascertainment bias due to enrichment by extremely G2-sensitive individuals would influence the heritability estimate in an upward direction, and this could account for the difference between their value of 82% and our value of 67% for the proportion of the variance attributed to the putative major gene.
Yet, like any SNP genotyping panels, the STAR Consortium panel, determined by an ascertainment panel consisting of SS/Jr, GK/Ox, SHRSP/Bbb, WKY/Bbb and F344/Stm strains [ 12], is subject to the ascertainment biases observed in SNP panels in general [ 16] that can impart large effects on many metrics of linkage disequilibrium [ 17].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com