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In this manner the data set is not limited by any additional annotation being available and allows inclusions of a much larger set of protein structures.
The complete list of all the sequences of the 72 ncRNA candidates is provided as Additional File 3. Searches of the RFAM database using BLAST on these 72 sequences did not provide any additional annotation information, suggesting that these may be trypanosome specific ncRNAs, or alternatively the sequence similarity to other organisms is too low to be detected.
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The key difference is that our RNA-seq analysis does not require any additional annotations beyond adding SNPs, and it still supports a novel 'transcript discovery'.
COSMOROE [60], a corpus-based framework used in this work as an additional annotation scheme, provides such a mechanism for the description of how multimedia information interact to convey a meaning.
Thus, our result suggests that we could add an additional annotation to PTPN22, namely enteritis.
(1) The annotation script includes a 'model' option that can be used to specify a well-studied species to use as an additional annotation source.
This technique is a visual representation that combines gene expression data and any form of additional annotation.
Like de novo genome assembly, de novo transcriptome assembly does not rely on any reference genome or additional annotation information, but is more difficult.
Emu can read a number of popular label and data file formats and supports overlaying additional annotation with inter-token relations on existing time-aligned label files.
Moreover, our system can further improve its performance significantly when incorporating additional training data, by taking advantage of existing database curation at no additional annotation cost.
In this work, we aim to improve the best results obtained in the challenge by combining a rich-feature machine learning approach with additional training data obtained without additional annotation cost from existing entries in curated databases.
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