Sentence examples for anxious phenotype from inspiring English sources

Furthermore, the anxious phenotype also depends on characteristics of the behaviour test used.

The WKY rat also displays visceral hypersensitivity [30] and a highly anxious phenotype [39].

Repetitive intrathecal application of purified patient IgG in rats resulted in an anxious phenotype resembling the core symptoms of the patient.

The following aim was to define whether the irradiation-induced reduction of neurogenesis hinders the development of an anxious phenotype by voluntary wheel running.

In contrast, hippocampal BDNF levels were not altered by irradiation and thus did not correlate with the development of an anxious phenotype.

However, the anxious phenotype of the patients which often resembles agoraphobia and not rarely entails substance abuse, often leads to a misdiagnosis of a primary psychiatric disorder and must clearly be attributed to supraspinal pathology.

Importantly, this deficit in GABAAR function associates with increased behavioural responses to aversive stimuli such as novelty, exposed space and brightly illuminated areas, all indicative of an anxious-like phenotype (Crestani et al., 1999).

A potential physiological role for neurosteroids in the programming of the stress response was first proposed following the observation that administration of 5α3α-THPROG reduced the number of ultrasonic vocalisations (USVs), a measure of an anxious-like phenotype, in neonatal rat pups (P7) previously exposed to maternal separation (Zimmerberg et al., 1994, 1999).

These sex-specific effects are likely to be a consequence of increased peripherally derived steroids (e.g. estrogen, progesterone) in females, as overectomised (OVX) female rats exposed to maternal separation exhibited an anxious-like phenotype on the EPM comparable to that observed in males.

The observation that the development of a hyperactive HPA axis during the neonatal period associates with an anxious and depressive adult phenotype when a genetically-engineered γ2-GABAAR deficit is introduced embryonically, but not in the fourth postnatal week, is intriguing in this regard.

Our results also support the idea that GRM7 rs3795245 polymorphism represents certain phenotypes such as anxious ADHD as well as the ADHD diagnosis itself.