Exact(41)
Over the past 70 years, antimicrobials have become increasingly ineffective as organisms develop resistance to the drugs that are supposed to kill them.
Although new antimicrobials have been developed in order to overcome drug-resistant bacteria, many are structurally complex β-lactams or quinolones.
New high-dose and/or extended-release formulations of traditional antimicrobials have been added to the current armamentarium for treatment of community-acquired respiratory tract infections.
Streptomycin was discovered in 1944, and since then many other antibiotics and other types of antimicrobials have been found and put into use.
While industrial efforts to find and develop novel antimicrobials have been severely reduced during the past two decades, the increasing threat of multidrug-resistant pathogens and the development of new technologies to find and produce such compounds have again attracted interest in this field.
Naturally occurring antimicrobials have been widely incorporated in gelatin film, including chitosan [5, 6], lysozyme [7], essential oils [8, 9], and nisin [10].
Similar(19)
Antimicrobials had no effect on WVP.
These natural antimicrobials had good antimicrobial effects and they can be an attractive green alternative for use as sanitizers.
The prevalence of S. pneumoniae resistance to common antimicrobials has increased over recent years.
Amphiphilic antimicrobial polymers, which have roots coming from antimicrobial peptides, show promise as potent antimicrobials having low susceptibility for developing resistance, unlike small molecular antibiotics.
Furthermore, the number of bacteria resistant to current synthetic antimicrobials has increased dramatically [22, 24, 25].
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