Exact(8)
We identified many abundant antimicrobial peptides, as well as novel proteins with potential antimicrobial roles.
Each of these proteins have potential immune roles; while ELP and WAP are both thought to prevent degradation of Igs in the gut76,77, WFDC2 and VELP likely play antimicrobial roles.
BEHPEI could play dual antimicrobial roles that were, the betaine ester-shell acted as contact-based antibacterial polycations and the drug-loaded BEHPEI could controllably release the drugs due to the cleavage of the betaine ester groups under weak alkaline condition.
It is well known that the molluscan immune system is based on innate mechanisms, whereas humoral and cellular processes approve cytotoxic and antimicrobial roles (Auffret, Rousseau, Boutet, Tanguy, & Baron, 2006).
β-defensins have been revealed to have more other biological activities in addition to their broad-spectrum antimicrobial roles [20], [21], [22], [23], [24].
"Monotreme milk represents a rich source of untapped and potentially novel bioactive proteins with developmental or antimicrobial roles," he says.
Similar(52)
This preliminary study encourages further work on dietary ACV supplementation investigating its antimicrobial role and the constituents which could be responsible for this activity.
This includes the high abundance of trichosurin and A1BG, potentially linked to the specialised diet of the koala, and the very high abundance of VELP which likely has an antimicrobial role.
Further studies on the chemical structure of this cell communication compound are warranted in the future work alongside the elucidation of any antimicrobial role of the pheromone itself, or the newly described, co-produced precursor fragment (ComE coming from Com-Elham).
Hence there was a case for a direct antimicrobial role.
It should also be noted, that PrP, as well as the studied peptides (with the exception of the signal peptide, MAN28) lost their antimicrobial activity at high salt strength, casting doubt of the potential antimicrobial role of PrP in vivo.
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