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Exact(11)
The primary end point was initial antimicrobial adequacy.
These patients were considered not evaluable when determining antimicrobial adequacy and were excluded from the analysis.
Although early use of broad-spectrum antimicrobials significantly increased initial antimicrobial adequacy, treatment outcomes were not improved.
Previous studies, however, have reported that DE was associated with higher antimicrobial adequacy and more favorable outcomes [ 6, 25- 27].
The higher antimicrobial adequacy observed in the DE group was mainly due to MRSA coverage by early administration of vancomycin.
First, our strategy may have improved antimicrobial adequacy for Gram-positive organisms, most of which were MRSA.
Similar(49)
Delayed administration of the initial dose of antimicrobial agents, the adequacy of antimicrobial therapy and, where applicable, delayed surgical source control, are all independent prognostic factors [ 5- 8].
To evaluate the relationship between the adequacy of antimicrobial treatment for bloodstream infections and clinical outcomes among patients requiring ICU admission.
Among them, we could notice that IE due to Streptococcus spp. were associated with a lower mortality than IE due to Staphylococcus spp. and that adequacy of antimicrobial and of surgical treatment also appeared as factors associated with survival.
Timing and adequacy of antimicrobial agents was evaluated together with their appropriateness according to local recommendations.
In this situation, both the precocity and adequacy of antimicrobial therapy are major prognostic factors [ 22].
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