Azole antifungal drugs featuring either an imidazole (e.g. miconazole, econazole, ketoconazole and clotrimazole) or a 1,2,4- triazole moiety (e.g. fluconazole and itraconazole) are the most widely used antifungal agents in clinics because of their safety profile and high therapeutic index [9].
Hyphal growth and multidrug resistance of C. albicans are important features for virulence and antifungal therapy of this pathogenic fungus.
It suggests that the predicted electronegative cleft from CkTLP may be an essential feature for the observed antifungal activity.
The features of the cysteine-rich antifungal proteins render them exceptionally suitable compounds as commercial preservatives, bio-pesticides and drugs against moulds and offer an alternative, safely applicable solution for the recent antifungal challenges (Marx et al., 2008; Meyer, 2008).
Furthermore, properly designed and executed animal experiments can readily demonstrate the effects (positive or negative) of combining antifungal drugs while simultaneously incorporating known clinical features associated with response to treatment.
This study demonstrates important differences in microscopic features of scraping material and antifungal susceptibility between the three groups.
We report a prospective study to compare different aspects of fungal keratitis such as its clinical features, microbial evaluation, molecular identification, antifungal susceptibility, and clinical outcomes.
'Empirical' treatment is defined as antifungal therapy given to patients with clinical features of an inflammatory response consistent with infection but without microbiological confirmation.
Moreover, better understanding of which features of chemical compounds decide high antifungal activity may provide further information useful for the improvement of antifungal action.
The second is an embryo-abundant protein of 109 amino acids that shares 85% similarity with an antifungal protein of Ginkgo biloba[ 44] but lacks the characteristic features of plant defensins.
