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We hypothesize that even with identical sample processing and storage protocols the environment and conditions of sample collection can affect the levels of biomarkers, and that these potential biases should be anticipated in biomarker validation study design.
The SNP selection was based on HapMap frequency data, validation, anticipated success rate on the Illumina platform, gene size, distribution across loci including 500 bp up- and down-stream of each gene.
The selection of 768 single nucleotide polymorphism (SNPs) for genotyping was based on HapMap frequency data, validation, anticipated success rate on the Illumina platform, gene size, distribution across loci, enrichment in coding changes, inclusion of sequence 500 bp up- and down-stream of each gene.
20 December 2014 Independent data validation anticipated being complete.
It is anticipated that respondent validation will be included in subsequent phases of the larger research program of which this study was a part.
Delineating the mechanisms for genetically acquired antibiotic resistance is a robust approach to target validation and anticipates the evolution of clinical drug resistance.
Further scale development and validation is anticipated as the suite comes into wider use.
We anticipate that once the validation is completed, it would provide adequate information on the psychometric properties of the Malaysian versions of the EORTC QLQ-C30 and CR29 for Bahasa Malaysia and Chinese Malaysia.
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