Thus, anti-inflammatory countermeasures can be anticipated to be efficacious for chlorine-induced lung injuries, whereas they can be anticipated to be ineffective or even contraindicated for phosgene.
2, 3 Combination therapies have also been reported to correlate with a high incidence of toxicity and high efficacies, therefore, the development of a well-tolerated, highly efficacious therapy is anticipated.
The present study included patients with antithrombin levels in the range of 50 to 80%, which was anticipated to be the most efficacious for mortality according to the stratified subgroup analyses of our prospective multicenter study [ 24, 30].
An efficacious BSV is anticipated to lead to a reduction in PMRs post CHMI, resulting either in a delay in time-to-diagnosis post CHMI or failure of individuals to be diagnosed post CHMI.
However, in the urgency to develop a medically efficacious microbicide, some of these concerns may not have been anticipated.
Similarly, it would not be anticipated that a B-cell-depleting agent such as rituximab would be efficacious.
Prophylactic HPV vaccines have been shown to remain efficacious for at least 10 years, 44 and so it can be anticipated that vaccinated women will continue to benefit from a reduction in disease risk in the long term.
Happily, these investments will not only increase the impact that existing interventions can have today, but will also lay the groundwork for eagerly anticipated ARV-based microbicidespeciallyally the vaginal ring with dapivirine, if and when it is demonstrated to be efficacious in clinical trials that will report out early next year.
If such nanomedicines ultimately prove in the clinic to be efficacious with manageable side effects, combination therapies together with radiation, chemotherapeutic agents and/or antiangiogenic drugs are anticipated to attack the thin film of viable tumour cells in the periphery of the tumour, which usually survives when vascular targeting agents are applied as anticancer therapeutics.
The following are anticipated specific contributions of the research: Clarify features and determinants of influenza vaccine acceptance that should guide policy to ensure that efficacious vaccines are also effective in the context of real public health action.
