Because RBR-2 and SPR-5 demethylases could redundantly target H3K4Me2 methyl marks, we anticipated that deficiency for both proteins might result in a strong synthetic interaction.
Informed by our findings with CD59a deficiency, we anticipated that CD55 deficiency would exacerbate disease.
One might anticipate that deficiencies of MyD88 or TLR function could impair clearance of Mp and lead to persistence of asthma symptoms associated with chronic carriage of the organism as observed by Kraft et al. [40].
Clonality, as tested by allele-specific polymerase chain reaction of X chromosome transcripts in females, appears as a relatively early sign, anticipating cellular deficiency.
It was anticipated that DNMT3L deficiency would predominantly be associated with increased transcription as a consequence of a looser chromatin state and increased access of transcription factors to gene promoters.
It was anticipated that Fxr deficiency could aggravate effects of the model hepatotoxic compound cyclosporine A (CsA).
We anticipated that periostin deficiency would protect from allergen-induced inflammation and hyperresponsiveness, but we found the opposite effect.
It was anticipated that Fxr deficiency could aggravate toxicity of CsA in PCLS and pinpoint to novel genes/processes regulated by FXR.
It was anticipated that Fxr deficiency could aggravate the hepatotoxicity of CsA and pinpoint to novel genes/processes regulated by FXR.
And although Eurotunnel officials privately put much of the blame on the slow response of the French fire brigade, its own people had not anticipated many of the deficiencies in the fire brigade's response.
