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PJS reports support from Sunesis for clinical trial management during the conduct of the study; consultancy/speaker fees from Ariad, Incyte, and Novartis; and pending patents for anticancer technologies and shareholder interest in JSK Therapeutics and Lone Star Thiotherapies outside the submitted work.
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Patrick Soon-Shiong, a self-made billionaire through injectable and breakthrough nanoparticle anticancer technology drug development, is now focusing his philanthropic efforts on creating a national highway for health care.
For instance, a small molecule inhibitor can decrease the activity of a target molecule, which may ultimately affect the efficacy of an anticancer drug; likewise, technology based on RNA interference (e.g. small interfering RNA) can downregulate the expression of a gene of interest which may ultimately impact on the melanoma sensitivity to a given treatment.
Such cancer-enabling PPIs will become promising therapeutic targets in anticancer strategies as the technologies in PPI modulator discovery and validating agents in the clinical setting advance in the future [ 15].
We have applied this technology to several anticancer drugs.
This PDAC microtissue, closely recapitulating key PDAC microenvironment characteristics, provides a valuable tool to elucidate the complex stroma cancer interrelationship and could be used in a future perspective as a testing platform for anticancer drugs in tissue-on-chip technology.
We identified proteins thought to mediate anticancer drug resistance using recent proteome technology and identified α-enolase as a true cisplatin chemoresistance factor.
For example, the technology using CNTs as anticancer agent delivery systems is also useful for drug delivery systems targeting noncancer diseases.
Nab-paclitaxel is among the first of a new class of anticancer agents to incorporate albumin particle technology and exploit the unique properties of albumin, a natural carrier of lipophilic molecules in humans.
To enhance screening, evaluation of anticancer drugs, we have applied optical imaging technology to this assay.
For these reasons, drug delivery technology research has focused on targeting anticancer drugs to a specific site or to develop intratumoral or intralesional injections to provide timed release profile for better management and cure of cancer (Rob et al. 2006).
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