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Our study may facilitate structure-based small molecule and antibody design to inhibit AL.
These results provide useful information for immunogen and therapeutic antibody design.
Encouraging data with the other approved antibodies, and with agents in clinical trials, suggest that rational antibody design will generate effective products for several different hematological malignancies.
If verified in the human setting, these findings have significant implications for antibody design, biomarker discovery, and the development of synergistic combinatorial therapies.
Insights from the models can be used to explore different formats, to set antibody design specifications such as affinity and valence, and to predict potency.
The impact of this approach depends on prudent selection of the target antigen, careful antibody design, appropriate subcellular targeting and stable accumulation of the recombinant antibodies in planta.
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