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Stavnezer, J. Antibody class switching.
Limon, J. J. et al. mTOR kinase inhibitors promote antibody class switching via mTORC2 inhibition.
McAdam, A.J. et al. ICOS is critical for CD40-mediated antibody class switching.
Our aim was to examine the potential of this antibody class to activate monocytes.
Chen, J. et al. The RNA-binding protein ROD1/PTBP3 cotranscriptionally defines AID-loading sites to mediate antibody class switch in mammalian genomes.
CD4T cells play a key role in humoral immunity by providing help to B cells, enabling effective antibody class switching and affinity maturation.
Compared to existing co-cultures, immune organoids provide a control over primary B cell proliferation with ∼100-fold higher and rapid differentiation to the GC phenotype with robust antibody class switching.
The enrichment of these immunoglobulins in egg yolk led Leslie and Clem to name this antibody class IgYs [3].
The Env-APRIL, Env-BAFF, and Env-CD40L gp140 trimers all enhanced the expression of activation-induced cytidine deaminase (AID), the enzyme responsible for inducing somatic hypermutation, antibody affinity maturation, and antibody class switching.
The basis of clinically relevant differences between individuals in antibody class and IgG subclass response polarisation needs to be investigated.
CD4+ T cells can regulate the activity of the immune response, determining B cell antibody class switching and secreting cytokines.
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