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Understanding the basic principles that govern RNA binding by aminoglycosides is important for the design of new generations of antibiotics that do not suffer from the known mechanisms of drug resistance.
"Ultimately, WHO's report should be a wake-up call to governments to introduce incentives for industry to develop new, affordable antibiotics that do not rely on patents and high prices and are adapted to the needs of developing countries".
When Flaherty mixed three antibiotics that don't affect sex ratio on their own (erythromycin, triclosan, and trimethoprim), the combo upped the percentage of males.
Scientists have yet to invent antibiotics that don't make you shit your brains out, but they have created a process that allows art historians to look deep into old paintings.
However, resistant bacteria acquire additional beneficial mutations during evolution in the absence of antibiotics that do not alter resistance directly but may modify the fitness effects of new resistance mutations.
New antibiotics that do not trigger a SOS response and do not lead to extensive lysis of the pathogen could also offer tools to curb the infection, as would molecules that compete with bacterial attachment to the intestinal mucosa.
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Recently, it was reported that about 25 – 50% of honey were bactericidal to S. aureus including methicillin-resistant strains and Pseudomonas aeruginosa overnight single-species biofilm, contrary to most of the antibiotics that did not show any effect [ 41].
The first vet diagnosed her condition as pneumonia and prescribed an antibiotic that didn't dent her illness.
This may result in a patient being given an antibiotic that doesn't work…," the BMJ says.
After all, if your doctor gives you an antibiotic that doesn't kill an infection, he or she should question the diagnosis, the treatment or both.
After the treatment of the cells with S. elongatus for 3 hours to overnight, the cells were washed with PBS three times and the medium was replaced by L-15 containing 100 µg/ml gentamicin, an antibiotic that does not cross the mammalian cell membrane.
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