We also did not use antibiotics as the intention was to compare haemodynamic and metabolic responses between species with an insult of comparable mortality.
Study of the microbiological profile and effectiveness of first intention antibiotic therapy in early respiratory infections.
First intention antibiotic therapy was empirical in every patient and initiated as soon as the diagnose was made.
First intention antibiotic therapy was considered effective in 74% of the patients and modified according to the microbiological profile in 7% and due to failure in 19% of the cases.
Increased knowledge and confidence amongst clinicians and parents were seen as key components that contributed to the reductions in antibiotic prescribing and intention to consult seen in the trial.
This study was designed to identify risk factors for the development of an early onset respiratory tract infection (ERI) and to review the microbiological profile and the effectiveness of first intention antibiotic therapy.
It was also registered length of oro-tracheal intubation, mechanical ventilation and ICU stay, comorbidities, risk factors for the development of respiratory tract infections, mechanical alterations of ventilation, microbiological profile obtained and first intention antibiotic therapy.
Increased knowledge and confidence amongst clinicians and patients were seen as key components that contributed to the reductions in antibiotic prescribing and intention to consult seen in the trial.
This might be one of the reasons why the intervention in this study led to fewer antibiotic prescriptions and intention to reconsult, while in other studies it had no effect.
According to the recommendations of ATS [ 2], first intention antibiotic therapy was, in 70% of the patients, amoxacilin+clavulanate or a third generation cephalosporin, which revealed to be a good option, with a failure rate of 23% in the patients to whom it was administered.
It is previously shown that an information exchange tool is effective in reducing the number of antibiotic prescriptions and intention to re-consult in children with upper respiratory tract infections and that such a tool can increase parental and clinician confidence in managing these illnesses [ 21, 35].
