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Meropenem, a carbapenem antibiotic displaying a broad spectrum of antibacterial activity, is administered in Medical Intensive Care Unit to critically ill patients undergoing continuous veno-venous haemodiafiltration (CVVHDF).
The objective of this study was to determine if inhaled salmeterol, a long-acting β2-adrenergic agonist, and oral doxycycline, a tetracycline antibiotic displaying matrix metalloproteinase (MMP) inhibitory activity, reduce airway inflammation and obstruction in cats with experimentally-induced asthma.
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Similar to a previous study [ 25– 28], in the present study this antibiotic displayed powerful PAEs: at 4x MIC alone, it exhibited nearly twice as long PAEs than when the antibiotic was used at 1x MIC against the tested strains.
Sometimes gentamicin is effective when other antibiotics display insufficient activity [50].
Animals given inhaled CO + antibiotics displayed significantly less ALI at 8 days postinoculation compared with antibiotics alone.
Liposome-entrapped antibiotics display higher reduction in CFU of endogenous P. aeruginosa in sputum compared to the free antibiotic suggesting its potency in CF lung infections.
If mosquitoes are infected with bacteria before being fed on malarious blood, they are less likely to be infected my malaria than if they are not infected by the bacteria [12] [17], whereas mosquitoes treated with antibiotics display lower expression of immune genes and are more susceptible to Plasmodium infection [18] [19].
Generally, cyclic antibiotics display an increased activity and stability in comparison to their linear analogs.
Several clinically used antibiotics display postantibiotic effects, whereby inhibition of cell growth continues after removal of the drug from the media or environment.
Various combinations of plant metabolites with antibiotics displayed promising synergistic results such as combination of epigallocatechin gallate (EGCg) with various antibiotics [ 15], carnosic acid (benzenediolabietanediterpene -tetracycline combenzenediolabietanediterpene -tetracycline 16], and baicombinationone glucuronide)-beta-lactam combination as beta-lactamase inhibitor [ 17].
Nocathiacin I, a glycosylated thiopeptide antibiotic, displays excellent antibacterial activities against multidrug resistant bacterial pathogens.
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