Our initial screening shows that single-component non-toxic metallic NPs do not have antibiotic capability; 2a we thus turn to bimetallic NPs.
Importantly, A101 increased the aminoglycosides antibiotics' capability of killing P. aeruginosa biofilm.
Here, A101 was demonstrated to powerfully disrupt the multicellular aggregates and established biofilm of P. aeruginosa FRD1, and significantly increased the aminoglycosides antibiotics' capability of killing P. aeruginosa FRD1 biofilm.
Integrons contain genes that confer antibiotic resistance capabilities and are incorporated into bacterial genomes via genetic recombination.
In addition, the genera Amycolatopsis (Dávila Costa and Amoroso 2014; Singh et al. 2012), Actinomadura (Dirlam et al. 1990), and Pseudonocardia (Cafaro and Currie 2011) originally have attracted researchers' attention duo to their antibiotic producing capabilities.
The complete genome sequences of the rifamycin producers Amycolatopsis mediterranei[ 22, 23] not only revealed the special genomic features of the genus Amycolatopsis, but also confirmed it as a clade of rare actinomycetes potentially rich in antibiotic production capabilities.
In vitro drug release assays demonstrated that PCL/WPC nanofibers had higher antibiotic release capability than the PCL nanofibers.
These results suggested that A101-mediated biofilm dispersion increased the antibiotic's capability of killing bacterial biofilms by indirectly targeting to bacterial cells.
The treatment of P. aeruginosa infections is complicated due to its high intrinsic resistance to antibiotics and capability of developing/acquiring new mechanisms of resistance.
