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Antibacterial prophylaxis with lactoferrin in neutropenic patients.
Antibacterial prophylaxis should provide coverage of all likely pathogens, including aerobic and anaerobic organisms.
Antibacterial prophylaxis should probably not be performed in critically patients with neutropenia (Grade 2−, strong agreement).
Several studies and a meta-analysis have validated the benefits of antibacterial prophylaxis in patients with profound and prolonged neutropenia [44 46].
To the best of our knowledge, no study to date has validated such antibacterial prophylaxis strategies in ICU settings, and no data are available to assess ecological risk with regard to bacterial resistance.
Although reduction of the infection rate by prophylactic antibacterial treatment is not proved, it was a constituent of our treatment protocol and complies with recent recommendations demonstrating benefits from broad-spectrum antibacterial prophylaxis in cases of necrotizing pancreatitis proven by CECT [18, 19].
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If administration of antibacterial drug prophylaxis is decided on, the preferred drug regimen will have to be determined.
Moreover, the majority of selective decontamination of the digestive tract regimens included either concurrent systemic or topical antibacterial antibiotic prophylaxis in the treatment group, which might increase the risk of fungal infection in that group relative to the placebo group.
This manuscript summarizes the recommendations on antibacterial and PCP prophylaxis for neutropenic cancer patients resulting from this process.> Guidelines for antiviral and antifungal prophylaxis can be found in other publications of the AGIHO [ 4, 5].
For leucopenia, antibacterial and antifungal prophylaxis are currently not recommended for patients with solid tumors who are undergoing conventional chemotherapy34.
Antibacterial and antifungal prophylaxis were not used.
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