Sentence examples for antagonize the development from inspiring English sources

IFNγ is known to antagonize the development of Th17 cells [53], [54] and can induce apoptosis of self-reactive T cells [55].

Finally, angiogenesis has a key role in the growth of tumors, suggesting that interference with angiogenesis may prevent or antagonize the development of HCC.

IL-6 is a key cytokine that has been implicated in autoimmune disease; it supports the development of IL-17-producing T effector cells (Th17) and antagonizes the development of Tregs.

These authors showed that inhibition of calcineurin/NFAT signaling increases the number of myeloid progenitors, and that the two calcineurin inhibitors CsA and FK506 antagonized the development of DCs induced by the Fms-related tyrosine kinase 3 ligand (Flt3-L).

Another possibility would be to combine a cell-based Treg therapy with a biologic agent that maintains the desired functional state of Tregs (Tang et al., 2008), or which antagonizes the development of T-effector cells, perhaps by interfering with the IL-6 pathway (Fig. 3C).

61 In addition T-bet directly antagonizes the development of the Th2 and Th17 lineages, by suppressing the function of the lineage defining transcription factors GATA3 (GATA binding protein 3) and RORγt (retinoid acid receptor-related orphan receptor gamma t) respectively.

This antibody is at the vanguard of a host of therapeutic compounds that are under development to antagonize the acivities of ErbB family receptors.

One of the functions of the TGF-β/Smad pathway during mammary gland development is to antagonize the prolactin/JAK/STAT pathway during the control of mammary gland growth, differentiation, and lactation.

Significant efforts have been devoted to the development of ALK inhibitors to antagonize the kinase activity of ALK.

The role of auxin is well-characterized in plant growth and development but yet, it is also long known to antagonize the ABA-induced stomatal closure [ 11].

However, when FOXO3a is active, FOXO3a can antagonize the estrogen-dependent functions of ER-α and ER-β, resulting in suppression of ER-mediated tumor growth and development.