Moreover, the abbreviated TTP (2.5 to 2.9 months) observed in this trial suggests a possible antagonistic interaction between gefitinib and trastuzumab.
This was because the younger subjects had stronger PF muscles and therefore greater antagonistic torque during the isometric DF trials.
AY and BX trial performance indices tend to be antagonistic (e.g., Braver, Satpute, Rush, Racine, & Barch, 2005), but are not necessarily so.
The conclusions which were drawn from the results of Trial A-3 were that synergistic and antagonistic interactions were not apparent and that the methane yields generally increased with increased substitution of waste activated sludge with poultry manure.
IL-4 antagonists prevent the development of allergic disease in vivo and an antagonistic variant of human IL-4 is now in clinical trials for asthma.
Defendants generally prefer juries, but police officers often go for bench trials in the Bronx, where they fear antagonistic jurors.
CARS: compensatory anti-inflammatory response syndrome; HLA: human leukocyte antigen; IFN: interferon; IL: interleukin; ISS: injury severity score; MARS: mixed antagonistic response syndrome; MOF: multiple organ failure; RCT: randomized controlled trial; SIRS: systemic inflammatory response syndrome; TNF: tumor necrosis factor.
We propose the pooled analysis of Phase II clinical trials as a methodology to develop a catalog of synergistic and antagonistic drug combinations.
In contrast, we found that the combination docetaxel+doxurubicin was synergistic based on the Phase II trials clinical data of breast cancer, while the combination of docetaxel+epirubicin was antagonistic, albeit in lung cancer.
Moreover, our data obtained from the field trials showed that some of S. litura pheromone isomers play a sygnergistic or antagonistic role when mixed into the sex pheromone blend (Du et al., unpublished result).
The robustness of this assumption was tested by carrying out subgroup analyses comparing results in trials with cointerventions following a protocol versus trials with cointerventions at the discretion of the physician to explore potential additive (synergistic) or subtractive (antagonistic) effects.
