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Alternative splicing is a posttranscriptional modification process that has been shown to be involved in the regulation of apoptosis by promoting the translation of multiple proteins from a single gene that results in a sometimes functionally heterogenic pool of proteins with antagonistic functions [ 33, 34].
Given the cancer-relevant and antagonistic functions of KLF6 and KLF6-SV1 it will be important to define the functionality of the putative NLS, the 5BR, as well as the role of nucleo-cytoplasmic shuttling in regulating KLF6/KLF6-SV1 function.
Ramirez-Carrozzi, V. R. et al. Selective and antagonistic functions of SWI/SNF and Mi-2beta nucleosome remodeling complexes during an inflammatory response.
Ramirez-Carrozzi, V.R. et al. Selective and antagonistic functions of SWI/SNF and Mi-2β nucleosome remodeling complexes during an inflammatory response.
We found that the antagonistic functions integrated in E3 ubiquitin ligases can prevent any undesirable sustained activation of downstream genes when E3 ubiquitin ligases are destabilized by unexpected perturbations.
Virus induced gene silencing technology revealed that both JcPIP1 and JcPIP2 have positive roles in response to water deficit stresses, but have antagonistic functions at the recovery stage.
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These results indicate that the ER export signal mimic is critical to the antagonistic function of p22, shown herein to be a novel antagonist of ER/Golgi trafficking.
Takeda, N. et al. Differential activation and antagonistic function of HIF-α isoforms in macrophages are essential for NO homeostasis.
One compound presented a favorable profile with an apparent neutral hPRB antagonistic function, a selective cherry-hPRB nuclear translocation and a cytostatic effect.
Together, these genetic interactions demonstrate that JMJ13 functions as an H3K27me3 demethylase that partially antagonizes the H3K27 methyltransferase CLF in vivo, although further investigation would be required to reveal the details of crosstalk between CLF and JMJ13 and whether the phenotypic suppression is due to direct antagonistic function at particular loci.
Furthermore, SUVH genes (i.e., SDG714, SDG727, and SDG710) are found to have an antagonistic function to the histone H3K9 demethylase gene JMJ706 in regulating H3K9 methylation and panicle development (Qin et al. 2010).
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