Indeed, we have observed several direct and inverse statistical correlations between the tested Suppressive miRNAs in the clinical melanoma specimens, which could suggest synergistic or antagonistic effects among them (data not shown).
This hypothesis is supported by our data showing the antagonistic effect of LPA on the LEF/TCF-dependent transcription induced by mutant form of β-catenin, β-catenin-ΔGSK-GFP (Figure S6).
In fact, at least in the case of p53 there is mounting data challenging the antagonistic pleiotropy model.
These data demonstrate an antagonistic relationship between miR-294/302 and let-7 in regulating EMT in ESCs.
Combined with the fact that Prospero represses expression of Asense, these data support an antagonistic relationship between Prospero and Asense.
The reference standard of glabridin did not have antagonistic properties towards the ERβ (data not shown) but was shown to be an ERα-selective antagonist (Fig. 5).
Further, our data suggest an antagonistic functional connection between BRG1 and MYC, whereby, refractoriness to RA and GC by BRG1 inactivation involves deregulation of MYC activity.
Collectively, our data demonstrated an antagonistic property of BAY11 to the in vitro and in vivo IFN response and imply a possibility for new therapeutic approaches by interference with the pathogenic components of autoimmune disorders.
However, on concurrent exposure of AI cells to paclitaxel plus vinorelbine, the calculated combination indexes were found to be between 1.5 and 3.8, suggesting an antagonistic to moderate additive effects (data not shown).
Although, more experimental evidence is required to draw definite conclusions and to understand the mechanisms involved, these data suggest an antagonistic function between the tumour suppressor BRG1 and the MYC oncogenes, that is consistent with the mutually exclusive presence of BRG1 inactivation and MYC amplification in lung cancer (Medina et al, 2008).
