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A single antagonistic correlation was defined as one miRNA cluster that positively correlated with a gene signature and another cluster that negatively correlated with the same gene signature.
Gene pairs 2 and 3 show no antagonistic correlation in expression level that could suggest potential tissue specific antagonistic effects between sense and antisense.
The complexity of human diet, especially the high synergistic or antagonistic correlation among the effects of various nutrients and foods, makes it difficult to examine their distinct effects.
The first number in each cell represents the number of gene signatures for which an antagonistic correlation was found (p < 0.001).
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In general, fatty acids such as conjugated linoleic acid (CLA) and 11t C18:1, with potential health benefits, showed significant antagonistic correlations with unhealthy fatty acids such as C14 0 and C16:0.
(f) Non-linear rate laws and antagonistic, correlation-generating mechanisms might impair reconstruction quality.
The upper right half of each table contains the agonistic correlations (which were not further considered), and the lower left half contains the antagonistic correlations.
More recently, Morrissey et al. (2012b) used a multivariate method proposed by Agrawal and Stinchcombe (2009) to provide evidence for genetic constraint through antagonistic correlations between female adult survival and female reproductive traits.
An alternative explanation, however, is that evolution can sometimes be constrained by antagonistic genetic correlations (i.e., genetic correlations among traits that are not in accord with the direction of selection [ 26, 27]) arising from linkage disequilibrium between alleles at different loci, and patterns of linkage disequilibrium can vary among populations or seasons [ 28, 29].
However, this conventional approach is hindered by antagonistic genetic correlations between some traits and the high cost of measuring body composition traits.
Assuming evolutionary processes in the absence of dispersal, the species most threatened by extinction are those that cannot evolve quickly enough relative to the rate of climate change owing to inadequate genetic variation, high maladaptive gene flow, antagonistic genetic correlations, or long generation times.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com