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In conclusion, we have provided evidence that KCNJ3 contributes to schizophrenia in Asian populations, adding another susceptibility candidate gene to the "channelopathy theory of psychiatric illnesses".
Therefore, it is conceivable that these interactions may result from this SNP being tightly linked to another susceptibility genetic variant of biological importance.
While for another susceptibility locus of rs116909674 at 14q13.3 which we checked, none of the studied Chinese family members carried the risk alleles.
Thus, it is perhaps more tempting to speculate that the TPSN 01 polymorphism (TPSN 260Arg) associated with SoJRA might be in LD with another susceptibility allele in a gene such as Daxx (or other genes in the region that play roles in apoptosis).
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Remarkably, some IgCAMs have been shown to interact with ITGAM, the product of another SLE susceptibility gene recently discovered in two independent genome wide association (GWA) scans.
No evidence for G×E interaction was obtained with another major susceptibility gene LOC387715 and smoking (p = 0.14) whereas the G×E interaction with sex (p = 1.04×10−6) was shown using MI statistics.
Dysbindin is another schizophrenia susceptibility gene, which plays a role in dopamine receptor trafficking [ 218].
Another SLE susceptibility gene codes for IRAK1, which is involved in TLR-triggered signal transduction [ 98].
Of note is another hereditary susceptibility gene that also appears to regulate the same pathway.
Another candidate susceptibility gene in Inf2 is Notch4, and just proximal to Inf2 is Notch3.
We believe that these results are sufficient to suggest another genetic susceptibility (PDCD1) for AS.
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