"It means we have a substantial issue likely to result in reversal," she said.
"So when you have 500 or 1,000 people who are misallocated, it's a fairly substantial issue.
She was an unpopular politician and failed to defend the poor or hold any remarkable stand on any substantial issue.
While no one keeps state-by-state numbers on parole backlogs, Mr. Mauer said, "nobody here is aware of that being a substantial issue in other states".
"It's probably the most substantial issue" facing Internet broadcasters, said Dave Goldberg, vice president and general manager for music at Yahoo, which operates a Web music service.
Sexual behaviour, therefore, became a substantial issue between him and his converts, and for that reason his letters frequently refer to sexual ethics.
The player, Muhammed Lasege, a 6-foot-11 native of Nigeria, won an injunction against the N.C.A.A. when Judge Geoffrey Morris ruled that Lasege had raised a substantial issue as to whether the N.C.A.A.'s decision on his eligibility was arbitrary.
Justice DiNoto ruled that the "evidence was sufficient to raise a substantial issue as to whether the stated reason for singling out Nassau and New York City for Article 18 treatment was, and continues to be, rational".
"This is the place where the administration made a clear decision that it can get something done with or without Congress, and it can do something politically on a substantial issue".
For a supposedly savvy woman, our protagonist seems alarmingly unwilling to question the processes that led to this less-than-positive experience, or to probe beyond her own navel into any substantial issue surrounding pregnancy.
