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The phrase "another significant issue is" is correct and usable in written English.
It can be used when introducing an additional important topic or concern in a discussion or analysis.
Example: "While we have addressed the budget constraints, another significant issue is the lack of resources for staff training."
Alternatives: "another important matter is" or "a further key concern is".
Exact(4)
Another significant issue is the protection of shareholder or partnership interests.
Another significant issue is that the White House initiatives, like the charitable choice rules, allow groups that receive government money to discriminate based on religion in deciding whom to hire and fire.
Another significant issue is to investigate mA-mediated biological functions from the angle of RNA demethylases.
Another significant issue is referral with evidence from the US suggesting that role substitution has led to increases in rehospitalisation and in use of specialists [ 30].
Similar(54)
But the significant issue is that they have another illness and the symptom of that is the overeating".
"But the more significant issue is location rather than height.
The most significant issue is the Florida "Stand Your Ground" law.
The most significant issue is the relation between hearing loss and dementia.
One significant issue is the laxity of the vaginal introitus.
A more significant issue is the status of Daltonian chemistry as an experimental science.
One significant issue is that of the teaching workload, particularly for those tutors tasked with creating their own materials.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com