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The fact that a significant proportion of microorganisms are not amenable to culture [3] is another serious drawback of those techniques.
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However, a serious drawback is its unfairness.
It could yet prove a serious drawback to his appointment.
The most serious drawback to the drug is its addictiveness.
A more serious drawback to using theoretical models is their lack of flexibility.
The Evil Dead fails even to horrify – always a serious drawback in a horror movie.
That, in particular, was a serious drawback, said Dr. David Freedman, a statistician at the University of California.
Lots of powerful technologies have a serious drawback: they generate way too much noise.
But a temporary view, however glorious, does have one serious drawback: It spooks apartment buyers.
There are many health and environmental implications of fracking, but flammable tap water appears to be an indubitably serious drawback.
It's a lovely place, but there is one serious drawback: it's hard to get connected.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com